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Synthesis Strategy of Tetrapyrrolic Photosensitizers for Their Practical Application in Photodynamic Therapy

Koifman, O. I.; Ageeva, T. A.; Kuzmina, N. S.; Otvagin, V. F.; Nyuchev, A. V.; Fedorov, A. Y.; Belykh, D. V.; Lebedeva, N. S.; Yurina, E. S.; Syrbu, S. A.; Koifman, M. O.; Gubarev, Y. A.; Bunin, D. A.; Gorbunova, Y. G.; Martynov, A. G.; Tsivadze, A. Y.; Dudkin, S. V.; Lyubimtsev, A. V.; Maiorova, L. A.; Kishalova, M. V.; Petrova, M. V.; Sheinin, V. B.; Tyurin, V. S.; Zamilatskov, I. A.; Zenkevich, E. I.; Morshnev, P. K.; Berezin, D. B.; Drondel, E. A.; Kustov, A. V.; Pogorilyy, V. A.; Noev, A. N.; Eshtukova-Shcheglova, E. A.; Plotnikova, E. A.; Plyutinskaya, A. D.; Morozova, N. B.; Pankratov, A. A.; Grin, M. A.; Abramova, O. B.; Kozlovtseva, E. A.; Drozhzhina, V. V.; Filonenko, E. V.; Kaprin, A. D.; Ryabova, A. V.; Pominova, D. V.; Romanishkin, I. D.; Makarov, V. I.; Loschenov, V. B.; Zhdanova, K. A.; Ivantsova, A. V.; Bortnevskaya, Y. S.; Bragina, N. A.; Solovieva, A. B.; Kuryanova, A. S.; Timashev, P. S..

Macroheterocycles ; 15(4):207-302, 2022.

Article in English | Web of Science | ID: covidwho-2327955

ABSTRACT

This review presents a wide range of tetrapyrrole photosensitizers used for photodynamic therapy (PDT), antimicrobial photodynamic therapy, photoinactivation of pathogens. Methods of synthesis and design of new photosensitizers with greater selectivity of accumulation in tumor tissue and increased photoinduced antitumor activity are considered. The issues of studying the properties of new photosensitizers, their photoactivity, the ability to generate singlet oxygen, and the possibility of using targeted photodynamic therapy in clinical practice are discussed. The review examines the work on PDT by national and foreign researchers.

ABSTRACT

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